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目的 探讨慢性脊髓压迫性损伤时 ,脊髓组织神经性一氧化氮合酶 (nNOS)免疫组织化学的变化及其与脊髓病理变化之间的关系。 方法 健康家兔 18只 ,随机分为正常对照组、实验对照组及实验组。实验组采用泛影葡胺囊逐级压迫复制慢性脊髓压迫动物模型 ,并持续逐级压迫脊髓 12周。取 3组家免相应脊髓节段 ,用Nissl染色观察脊髓的病理变化 ;用免疫组织化学方法对脊髓组织nNOS阳性运动神经元分布特点和nNOS含量变化进行分析。 结果 Nissl染色可见实验组脊髓压迫节段前角运动神经元损伤 ;实验组家免脊髓压迫节段前角nNOS阳性运动神经元较正常及实验对照组各个脊髓节段异常增加。 结论 在慢性脊髓压迫时 ,神经性NO合成增加
Objective To investigate the changes of neuronal nitric oxide synthase (nNOS) immunohistochemistry and its relationship with pathological changes of spinal cord in chronic spinal cord injury. Methods Eighteen healthy rabbits were randomly divided into normal control group, experimental control group and experimental group. Experimental group using meglumine diatrizoate-level compression of chronic spinal cord compression of animal models, and continued compression of the spinal cord for 12 weeks. The corresponding spinal cord segments were removed from the three groups. Nissl staining was used to observe the pathological changes of spinal cord. The distribution of nNOS positive motor neurons and the changes of nNOS content in spinal cord tissue were analyzed by immunohistochemistry. Results Nissl staining showed that the nNOS positive motor neurons in the anterior horn of spinal cord in the experimental group were more abnormal than those in the normal and experimental control groups. Conclusion During chronic spinal cord compression, neurogenic NO synthesis increases