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目的评价高压氧(HBO)综合治疗对小儿脑瘫运动功能的影响。方法采用随机区组配对的统计学方法,将57例小儿脑瘫患者(平均年龄2.3±1.3岁)分为两组:HBO治疗+常规治疗组(HBO组,n=31,0.16～0.20MPa)和常规治疗组(n=26)。评价治疗前、治疗1,2,3个疗程后肌张力(Ashworth指数)、总运动功能评分(GMF评分)。所有首次HBO治疗的患儿在3个月内接受30次(3个疗程)的HBO治疗。通过SPSS12.0统计软件对组内、组间数据进行Wilcoxon符号秩检验。结果HBO组:1个疗程后,Ashworth指数降低(P<0.05);2个疗程后,GMF评分降低(P<0.05)。其中<1岁组患儿的上述两个指标变化较其他两组明显(P<0.001)。结论HBO对轻症、早期(<1岁)脑瘫患儿的治疗效果最佳,对重症、病程长的患儿(>3岁)需要进行长疗程的HBO治疗。
Objective To evaluate the effects of hyperbaric oxygen therapy (HBO) on motor function in children with cerebral palsy. Methods Fifty-seven pediatric patients with cerebral palsy (mean age 2.3 ± 1.3 years) were divided into two groups: HBO treatment + conventional treatment group (HBO group, n = 31,0.16-0.20 MPa) and Routine treatment group (n = 26). Before treatment, after treatment 1,2,3-treatment of muscle tone (Ashworth index), total motor function score (GMF score). All first-time HBO-treated children received 30 HBO treatments over a 3-month period. Wilcoxon signed rank test was used to analyze the intra and inter group data by SPSS12.0 statistical software. Results In HBO group, Ashworth index decreased after one course of treatment (P <0.05). After two courses of treatment, GMF score decreased (P <0.05). The changes of the above two indexes in children <1 year old group were more obvious than those in the other two groups (P <0.001). Conclusions HBO is the best treatment for children with mild and early cerebral palsy (<1 year old). HBO treatment is required for children with severe and longer duration (> 3 years old).