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目的 探讨空腹血糖正常的非酒精性脂肪肝 (简称脂肪肝 )形成的危险因素。方法 引用 2 0 0 3- 11-0 1～ 2 0 0 3- 11- 30深圳某区探访病调查资料中空腹血糖 <5 . 6mmol/L的脂肪肝患者 15 8例和正常对照 316名参加本研究 ,采用McAuley指数、稳态模式法胰岛素抵抗指数 (HOMA -IR)和空腹胰岛素 (FINS)评价胰岛素抵抗。结果 控制年龄和性别后与对照组比较 ,脂肪肝组体重指数、腰围、腰臀比、全身脂肪百分比、收缩压、舒张压、总胆固醇、低密度脂蛋白胆固醇、甘油三酯、HOMA -IR和FINS升高 (均为P <0 . 0 0 1) ,而高密度脂蛋白胆固醇和McAuley指数降低 (均为P <0 .0 0 1) ;Logistic回归分析显示 ,体重指数、腰围和McAuley指数是脂肪肝形成的独立危险因素。结论 空腹血糖正常者脂肪肝形成的独立危险因素是肥胖和胰岛素抵抗。
Objective To investigate the risk factors of non-alcoholic fatty liver (abbreviated as fatty liver) with normal fasting blood glucose. Methods References 2 0 0 3- 11-0 1 ~ 2 0 0 3- 11- 30 In a survey of SARS patients in Shenzhen, 15 8 cases of fatty liver with a fasting blood glucose <5.6 mmol / L and 316 healthy volunteers participated in the study In the study, insulin resistance was evaluated using the McAuley index, homeostasis model insulin resistance index (HOMA-IR), and fasting insulin (FINS). Results Compared with control group, body mass index, waist circumference, waist-hip ratio, percentage of body fat, systolic blood pressure, diastolic blood pressure, total cholesterol, low density lipoprotein cholesterol, triglyceride, HOMA- FINS (all P <0.001), and high density lipoprotein cholesterol and McAuley index decreased (all P <0.01). Logistic regression analysis showed that body mass index, waist circumference and McAuley index were Independent risk factors for fatty liver formation. Conclusion The independent risk factors of fatty liver formation in normal fasting blood glucose are obesity and insulin resistance.