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目的研究淋巴细胞免疫治疗对复发性流产患者免疫调节功能及妊娠结局的影响。方法选择2012年4月-2013年4月习惯性流产患者120例为研究对象,采用数字表法随机分为免疫治疗组和对照组,免疫治疗组进行淋巴细胞免疫治疗,对照组仅给予常规保胎治疗。比较2组患者的妊娠结局、免疫细胞以及免疫因子含量。结果妊娠结局:免疫治疗组患者妊娠成功率高于对照组,再次流产率低于对照组,差异有统计学意义(P<0.05);免疫功能:治疗后患者的CD4+T细胞数量以及免疫球蛋白(Ig G、Ig M)、TNF-α、IFN-γ含量低于治疗前,CD8+T细胞的数量以及IL-10、IL-13含量高于治疗前,差异有统计学意义(P<0.05)。结论淋巴细胞免疫治疗有助于改善复发性流产患者的妊娠结局,同时调节免疫功能,增强母体对胎儿的免疫耐受。
Objective To study the effect of lymphocyte immunotherapy on immune function and pregnancy outcomes in patients with recurrent spontaneous abortion. Methods A total of 120 patients with habitual abortion were selected from April 2012 to April 2013. The patients were randomly divided into immunotherapy group and control group by digital table method. Immunotherapy group received lymphocyte immunotherapy. The control group received routine immunization Tire treatment. Pregnancy outcomes, immune cells and immune factors were compared between the two groups. Results Pregnancy outcome: The success rate of pregnancy in immunotherapy group was higher than that in control group, and the rate of abortion was lower than that in control group (P <0.05). The immune function: The number of CD4 + T cells and immunoglobulin The levels of Ig G, Ig M, TNF-α and IFN-γ were lower than those before treatment, the number of CD8 + T cells and the levels of IL-10 and IL-13 were significantly higher than those before treatment (P < 0.05). Conclusion Lymphocyte immunotherapy is helpful to improve pregnancy outcomes in patients with recurrent spontaneous abortion, regulate immune function and enhance immune tolerance of the fetus to the fetus.