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目的分析加替沙星在临床静脉给药过程中的不良反应,总结有效的预防和治疗对策,为提高用药合理性提供参考。方法选择本院2012年1-12月静脉给药(加替沙星)出现不良反应的85例患者为研究对象,对其临床资料进行回顾性分析,并总结有效的预防和治疗对策。结果加替沙星静脉给药413例,出现不良反应85例,不良反应率20.58%;加替沙星引起的不良反应累及消化、呼吸、循环、中枢等多个系统,以皮肤过敏、消化道反应、及呼吸困难等为主要表现形式。结论加替沙星静脉用药临床不良反应发生率较高,应加强临床监管,并考虑患者过敏体质、年龄等个体化情况,做到合理用药。
Objective To analyze the adverse reactions of gatifloxacin in clinical intravenous administration and to sum up effective prevention and treatment measures to provide reference for improving the rationality of medication. Methods Eighty-five patients with adverse reactions of intravenous administration (gatifloxacin) in our hospital from January to December in 2012 were retrospectively analyzed and the effective prevention and treatment strategies were summarized. Results Gatifloxacin intravenous administration of 413 cases, 85 cases of adverse reactions, the adverse reaction rate was 20.58%; gatifloxacin-induced adverse reactions involving digestive, respiratory, circulatory, central and other systems to skin allergies, digestive tract Reaction, and breathing difficulties as the main manifestations. Conclusion Gatifloxacin has a high incidence of clinical adverse reactions, and clinical supervision should be strengthened. Consideration should be given to the individualization of patients with allergies, age, etc., so that rational use of drugs can be made.