Warfarin是一种抗凝血剂，能穿过胎盘屏障进入胎儿体内。在怀孕头三个月应用Warfarin导致的胎儿软骨过早钙化及鼻发育不全等称为胎儿Warfarin综合征（FoetalWar【armSyndrome，FWS）。在妊娠中、后三个月使用Warfarin还可引起胎儿体内出血和中枢神经系统异常和畸形等。据统计文 Warfarin is an anticoagulant that crosses the placental barrier into the fetus. Warfarin-induced fetal cartilage premature calcification and nasal hypoplasia in the first trimester of pregnancy are known as Fetal Warfarin syndrome (FWS). In the third trimester of pregnancy, the use of Warfarin can also cause fetal hemorrhage and central nervous system abnormalities and deformities. According to statistics