目的 :探讨肿瘤化疗患者血小板输注效果及影响因素。方法 :对 5 8例在化疗后出现严重血小板减少的恶性肿瘤患者 ,输注单采或多人份混合血小板悬液 ,并于输注前及输注后 1 h和 2 4 h后检测血小板计数 ,以校正血小板计数增值 ( CCI) ,判定输注效果并讨论其影响因素。结果 :单采组 CCI显著高于混合组 ;单采组及混合组输注有效率分别为 93.3%和 89.1 % ;感染组血小板及非感染组无效输注率 ( PTR)分别为 43.7%和 6.9% ,差异十分显著 ;单采组及混合组中不良反应发生率分别为 2 .4%和 6.3% ,差异十分显著。结论 :血小板输注是治疗因血小板减少导致出血的有效措施 ,单采血小板疗效更好 ,但是感染是影响血小板输注效果的一个重要因素 Objective: To investigate the effect and influencing factors of platelet transfusion in patients with tumor chemotherapy. Methods: Fifty-eight patients with malignant tumor with severe thrombocytopenia after chemotherapy were infused with single or multiplayer mixed platelet suspension. The platelet counts were measured before and 1 and 2 h after infusion , To correct platelet count value (CCI), to determine the infusion effect and discuss its influencing factors. Results: The CCI in the apheresis group was significantly higher than that in the mixed group. The effective rates of transfusion in the apheresis group and mixed group were 93.3% and 89.1%, respectively. Infected group, the invalid infusion rate (PTR) of platelet and noninfected group were 43.7% and 6.9% %, The difference is very significant; the incidence of adverse reactions in single and mixed groups were respectively 2.4% and 6.3%, the difference was significant. CONCLUSIONS: Platelet transfusion is an effective treatment for bleeding due to thrombocytopenia, and apheresis platelets are more effective, but infection is an important factor that affects platelet transfusion