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目的：建立具有良好的易行性和可控制性的，能应用于放射影像学研究的肺纤维化动物模型。方法：采用３种给药方法：①经气管插管平阳霉素滴注：②支气管插管雾化：③平阳霉素肺动脉灌注联合雾化给药。动态观察ＨＲＣＴ表现，行ＨＲＣＴ－病理对照研究。结果：动物均耐受了实验；出现了可靠的纤维化病变；早期ＨＲＣＴ可见支气管血管束周围模糊斑片影、小叶内毛玻璃影、大片状毛玻璃影，以及肺实变，病理对照显示为肺泡炎，肺出血及肺泡腔内渗出；２周后见小叶核增粗，出现胸膜下线、纤维条索影，病理对照显示纤维组织增生。ＨＲＣＴ所见肺内病变分布弥散，可延伸到胸膜下。结论：平阳霉素致犬肺纤维化模型是一种可靠、简单易行、具有良好的重复性及控制性的肺纤维化动物模型方法。
OBJECTIVE: To establish an animal model of lung fibrosis with good feasibility and controllability which can be applied to radiographic studies. Methods: 3 kinds of administration methods: ① intratracheal intrathecal Pingyangmycin instillation: ② bronchial intubation: ③ Pingyangmycin pulmonary perfusion combined with atomization. Dynamic observation of HRCT performance, line HRCT - pathological control study. Results: The animals were well tolerated by the experiment. Reliable fibrosis was observed. Early HRCT showed fuzzy patch around the bronchovascular bundles, intraocular glabresia, lobular glabrous glassography, and lung consolidation. The pathological controls showed alveolar Inflammation, pulmonary hemorrhage and alveolar exudate; lobular nuclear thickening after 2 weeks, there subpleural line, fiber strip cable shadow, pathological control showed fibrous tissue proliferation. HRCT lesions seen in the distribution of lung dispersion, can be extended to the subpleural. Conclusion: Pingyangmycin-induced canine pulmonary fibrosis model is a reliable, simple and easy to operate, with good reproducibility and control of animal models of pulmonary fibrosis.