论文部分内容阅读
目的探讨不同性别中正常血尿酸(SUA)水平与非酒精性脂肪肝(NAFLD)的关系。方法采用随机整群抽样法,调查2011年4—6月在新疆乌鲁木齐市第一附属医院与克拉玛依市接受健康体检的人员。按该人群男性和女性的SUA水平,以四分位数将男女各分为4组,测定体质指数(BMI)、腰臀比(WHR)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、天冬氨酸转氨酶(AST)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血尿酸(SUA)等指标。结果随着SUA水平升高,不同性别NAFLD的患病率均呈显著上升趋势。BMI、WHR、SBP、DBP、AST、TG、TC与LDL都随之上升,HDL随着SUA水平的上升而下降。采用Logistic回归分析男女不同尿酸水平分组下,NAFLD患病危险比分别为:男性B、C、D组分别为1.034(95%CI 0.783~1.366)、1.607(95%CI 1.223~2.11)、2.257(95%CI 1.719~2.964);女性分别为1.447(95%CI0.946~2.212)、1.562(95%CI 1.023~2.386)、3.49(95%CI 2.35~5.183)。结论即使尿酸水平在正常值范围内,尿酸水平不断上升仍然是非酒精性脂肪肝发病的一个危险因素。
Objective To investigate the relationship between normal serum uric acid (SUA) and non-alcoholic fatty liver (NAFLD) in different genders. Methods A random cluster sampling method was used to investigate the number of health check-ups in the First Affiliated Hospital of Urumqi and Karamay from April to June in 2011. According to SUA level of male and female in this population, men and women were divided into 4 groups according to quartile. Body mass index (BMI), WHR, SBP, DBP, fasting (FPG), triglyceride (TG), total cholesterol (TC), aspartate aminotransferase (AST), high density lipoprotein (HDL), low density lipoprotein (LDL) and serum uric acid (SUA) . Results With the increase of SUA level, the prevalence of NAFLD in different genders showed a significant upward trend. BMI, WHR, SBP, DBP, AST, TG, TC and LDL both increased, and HDL decreased with the rise of SUA level. Logistic regression analysis of different uric acid levels in men and women under the group, the risk of NAFLD risk were: male B, C, D were 1.034 (95% CI 0.783-1.366), 1.607 (95% CI 1.223-2.11), 2.257 95% CI0.946 ~ 2.212), 1.562 (95% CI 1.023 ~ 2.386) and 3.49 (95% CI 2.35 ~ 5.183) respectively. Conclusion Uric acid levels continue to be a risk factor for the development of Nonalcoholic Fatty Liver, even though uric acid levels are within normal limits.