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目的:研究口腔扁平苔藓(OLP)患者唾液和血清中骨桥蛋白(OPN)等细胞因子的含量及其相互关系。方法:经病理学检查确诊的OLP患者26例,其中充血糜烂型12型,网纹/斑块型14例。酶联免疫吸附试验(ELISA)检测患者唾液和血清中OPN,肿瘤坏死因子-α(TNF-α),转化生长因子-β1(TGF-β1)的含量。以26名健康志愿者作为正常对照。结果:OLP患者唾液和血清OPN,TNF-α含量与正常对照组相比均有升高(P<0.05);充血糜烂型OLP的TGF-β1唾液和血清水平显著高于网纹/斑块型OLP(P<0.05)。三种抗体在唾液和血清中表现出明显的相关关系。结论:OPN在OLP患者唾液和血清中含量升高,唾液和血清中OPN含量具有相关性。唾液作为无创伤性检测标本有望有限地代替血清标本应用于OLP与口腔白斑的临床检测。
Objective: To study the content and correlation of osteopontin (OPN) and other cytokines in saliva and serum of oral lichen planus (OLP) patients. Methods: Twenty-six OLP patients confirmed by pathology were included in this study. Among them, 12 were type of erosive erosions and 14 were textured / plaque type. Serum levels of OPN, tumor necrosis factor-α (TNF-α), and transforming growth factor-β1 (TGF-β1) were measured by enzyme linked immunosorbent assay (ELISA) Twenty-six healthy volunteers served as normal controls. Results: The levels of OPN and TNF-α in saliva, serum TNF-α in OLP patients were significantly higher than those in normal controls (P <0.05). The salivary and serum levels of TGF-β1 in OLP were significantly higher OLP (P <0.05). The three antibodies showed a significant correlation between saliva and serum. CONCLUSIONS: The levels of OPN in saliva and serum of OLP patients are elevated, and the contents of OPN in saliva and serum are correlated. Saliva as a non-invasive test specimens is expected to replace serum samples limited to OLP and oral leukoplakia clinical testing.