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目的观察甲状腺功能亢进药物治疗中脱发患者性激素水平变化。方法选择2012/2013年在作者医院甲亢中心门诊就诊的110例甲状腺功能亢进药物治疗中脱发患者为甲状腺功能亢进脱发组(男30例,女80例),作者医院健康体检人员60例为健康对照组(男30例,女30例),作者医院甲亢中心门诊就诊的无脱发甲状腺功能亢进患者60例为甲状腺功能亢进对照组(男30例,女30例),利用全自动免疫分析仪对患者血清性激素水平进行检测、研究。结果与健康对照组比较,甲状腺功能亢进脱发组男性雌二醇(estradiol,E2)、孕酮(progestin,P)明显升高,睾酮(testosterone,T)明显降低,组间比较差异具有统计学意义(P<0.01);甲状腺功能亢进脱发组女性E2、T及P明显升高,人促卵泡生成素(follicle-stimulating hormone,FSH)、人促黄体生成素(luteinizing hormone,LH)明显降低,组间比较差异具有统计学意义(P<0.01)。与甲状腺功能亢进对照组比较,甲状腺功能亢进脱发组男性P明显升高,E2、T明显降低,两组比较差异具有统计学意义(P<0.01);甲状腺功能亢进脱发组女性E2、P明显升高,FSH、LH及泌乳素(prolactin,PRL)明显降低,两组比较差异具有统计学意义(P<0.01)。结论男性甲状腺功能亢进脱发患者P明显升高,T明显降低;女性甲状腺功能亢进脱发患者E2、P明显升高,FSH、LH明显降低。
Objective To observe the changes of sex hormones in patients with alopecia during the treatment of hyperthyroidism. Methods One hundred and ten patients with hyperthyroidism who were treated in the Hyperthyroidism Outpatient Clinic of the author hospital in 2012/2013 were hyperthyroidism hair loss patients (30 males and 80 females), and 60 healthy subjects were selected as healthy controls (30 males and 30 females). 60 patients with hyperthyroidism without alopecia were selected as hyperthyroidism control group (30 males and 30 females) by using automatic immunoassay analyzer Serum sex hormone levels were tested and studied. Results Compared with healthy control group, estradiol (E2) and progestin (P) in male patients with hyperthyroidism were significantly increased, testosterone (T) was significantly decreased, and the difference between the two groups was statistically significant (P <0.01). The levels of E2, T and P in female with hyperthyroidism group were significantly higher than those in control group (P <0.01). The follicle-stimulating hormone (FSH) and luteinizing hormone (LH) The difference was statistically significant (P <0.01). Compared with hyperthyroidism control group, male P in hyperthyroidism hair loss group was significantly increased, E2, T was significantly decreased, the difference between the two groups was statistically significant (P <0.01); hyperthyroidism hair loss group female E2, P significantly increased High, FSH, LH and prolactin (PRL) were significantly decreased, the difference between the two groups was statistically significant (P <0.01). Conclusions P in hypertensive male patients with hyperthyroidism was significantly increased and T significantly decreased. The levels of E2 and P in female patients with hyperthyroidism and hair loss were significantly increased while the levels of FSH and LH were significantly decreased.