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从中草药提取具有确定药理作用的有效成分,进而从测定的化学结构出发作为一个先导化合物(lead compound),进行结构修饰,合成一系列更有效的化合物,以寻找高效低毒结构新颖的药物,是当今寻找新药、开展药物设计的主要途径之一.青蒿素(Oinghaosu,Artemisinin)是我同科学工作者近年来从中药青蒿(菊科植物黄花蒿Artemisia annua L.)中分离得到的貝行新型化学结构的抗疟药,它对治疗各种类型疟疾具有速效、低毒等优点,特别是抢救凶险型疟疾和治疗抗氯喹恶性疟方面具有特色.青蒿素作为抗疟药物已获得了国内外的广泛重视.青蒿素经与钠硼氢反应可产生一个羟基,还原为二氢青蒿素.我所
Extract active ingredients with definite pharmacological action from Chinese herbal medicine and proceed as a lead compound from the measured chemical structure to carry out structural modification to synthesize a series of more effective compounds to find new drugs with high efficient and low toxic structure, Nowadays, Oinghaosu (Artemisinin) is one of the main ways to find new drugs and drug design.Ishapeomycin (Artemisinin) is a kind of polyphenols derived from Chinese medicinal Artemisia annua L. (Artemisia annua L.) The new chemical structure of anti-malarial drugs, which has the advantages of quick-effect, low toxicity and so on in the treatment of various types of malaria, especially in the rescue of dangerous malaria and the treatment of anti-chloroquine falciparum malaria has the characteristics of artemisinin as antimalarial drugs have been domestic Outside the widespread attention of artemisinin and sodium borohydride reaction can produce a hydroxyl, reduced to dihydroartemisinin. I