成药中咖啡因和安替比林合剂的含量测定,美国Methods of Analysis-A.O.A.C.(1950年版587頁)采用碘重量法。此法操作麻煩,如应用于米格来宁Migranine)中,由于过濾、抽提等引起的誤差,测得咖啡因的含量,有时比加入量高出30%。如將其中的安替比林改用容量法,操作虽然簡單不少,但咖啡因的回收率有时約达120%。苏联成药分析(1950年版,373頁)中 Drugs caffeine and antipyrine mixture of content determination, the United States of America Methods of Analysis-A.O.A.C. (1950 edition 587 pages) using iodine weight method. This method is cumbersome to operate, as applied to migranine, and the caffeine content is sometimes measured 30% more than the amount due to errors due to filtration, extraction and the like. If the conversion of Antipyrine to volumetric method, though a lot of simple operation, but caffeine recovery sometimes about 120%. Analysis of the Soviet Union drug (1950 edition, 373 pages)