肝细胞癌是第6个最常见的恶性肿瘤,肝细胞癌与肝脏转移性肿瘤的区分常较困难,而它们的区分有助于以后的预后评估和治疗。目前在常规的外科病理诊断中确定肝细胞的有价值的诊断免疫组化标记物是HepPart-1、pCEA、CD10、AFP和glypican-3,然而,每个标记物或因敏感性欠佳或解释困难 Hepatocellular carcinoma is the sixth most common malignancy. It is often difficult to distinguish between hepatocellular carcinoma and metastatic liver tumors, and their differentiation can be helpful for the subsequent assessment and treatment of prognosis. Currently valuable diagnostic immunohistochemical markers to identify hepatocytes in routine surgical pathology are HepPart-1, pCEA, CD10, AFP and glypican-3, however, each marker may be either poorly sensitive or interpretable difficult