10多年来,细胞异质性作为肿瘤的基本特征这一点已被不断加深认识,肿瘤细胞的特征差异在表型的许多方面被反复证实,这些特征包括生长速度、转移能力、免疫原性、对治疗的敏感性和表型的稳定性。虽然肿瘤细胞异质性的观点目前已被广泛承认,但过于简单化,不能充分解释肿瘤的群体生物学特征。事实上,甚至从晚期癌也能分 For more than 10 years, the heterogeneity of cells as the basic characteristics of tumors has been continuously understood. The differences in the characteristics of tumor cells have been repeatedly confirmed in many aspects of phenotypes, including growth rate, metastatic ability, immunogenicity, and The sensitivity of treatment and the stability of the phenotype. Although the viewpoint of tumor cell heterogeneity has been widely recognized at present, it is too simplistic to fully explain the biological characteristics of tumors. In fact, even cancer from late stage can be divided