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目的分析醒脑静注射液对脑出血患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)及血清神经细胞特异性烯醇化酶(NSE)、S100β蛋白水平的影响。方法将自发性高血压脑出血患者120例随机分为观察组与对照组各60例。2组患者入院后均按照2014年中国脑出血诊治指南给予降低颅内压,适当控制血压等对症处理。观察组给予醒脑静注射液静脉滴注,对照组同期给予等量生理盐水静脉滴注。入组患者分别于入院后24h及72h晨空腹抽血5ml,采用酶联免疫吸附法检测血清TNF-α、IL-1β水平及化学发光法检测血清NSE,应用ELISA检测S100β蛋白水平。结果治疗后2组患者血清TNF-α、IL-1β与NSE、S100β蛋白水平均明显高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。结论醒脑静注射液可降低自发性高血压脑出血患者血清TNF-α、IL-1β、NSE及S100β蛋白水平,降低组织炎性反应,保护神经功能。
Objective To investigate the effect of xingnaojing injection on serum level of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), serum neuron specific enolase (NSE) and S100β in patients with intracerebral hemorrhage influences. Methods 120 patients with spontaneous hypertensive cerebral hemorrhage were randomly divided into observation group and control group of 60 cases. After admission, both groups were given symptomatic treatment to reduce intracranial pressure and blood pressure according to the guidelines for diagnosis and treatment of cerebral hemorrhage in China in 2014. The observation group was given Xingnaojing injection intravenously, the control group was given the same amount of saline intravenous infusion. The patients were enrolled in the study. Serum levels of TNF-α and IL-1β were detected by enzyme-linked immunosorbent assay (ELISA) and serum NSE was detected by chemiluminescence assay. S100β protein levels were detected by ELISA. Results After treatment, the levels of serum TNF-α, IL-1β, NSE and S100β in the two groups were significantly higher than those before treatment, and the difference was statistically significant (P <0.05). Conclusion Xingnaojing injection can reduce the levels of serum TNF-α, IL-1β, NSE and S100β in patients with spontaneous hypertensive intracerebral hemorrhage, reduce inflammatory reaction and protect neurological function.