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目的 探讨抑癌基因在多原发性恶性肿瘤 (MPMN)发生中的重要作用。方法 采用回顾性分析的方法对近年来多原发性恶性肿瘤中常见的相关抑癌基因研究进行了综述。结果 目前在多原发性恶性肿瘤研究中 ,研究较多的抑癌基因有 p5 3、APC、p16、BRCA1、BRCA2、PTEN/MMAC1等基因 ,许多MPMN可检测出相同的抑癌基因突变。 结论 多原发性恶性肿瘤发生与抑癌基因失活有重要关系 ,通过对抑癌基因在MPMN中作用的研究 ,可揭示出MPMN发生的某些共同规律。
Objective To investigate the important role of tumor suppressor gene in the development of multiple primary malignant tumors (MPMN). Methods Retrospective analysis was used to review the studies on the common anti-oncogenes associated with multiple primary malignancies in recent years. Results In the study of multiple primary malignant tumors, the most studied tumor suppressor genes are p53, APC, p16, BRCA1, BRCA2, and PTEN/MMAC1. Many MPMNs can detect the same tumor suppressor gene mutations. Conclusion There is an important relationship between the occurrence of multiple primary malignant tumors and the inactivation of tumor suppressor genes. The study of the role of tumor suppressor genes in MPMN can reveal some common patterns of MPMN occurrence.