报告7例原发性难治性肾小球疾病,临床治疗近期效果均不满意。肾活检结果系膜增生与局灶节段硬化性肾炎各2例,弥漫增生、膜性肾炎与新月体肾炎各1例,至今5年后随访结果痊愈3例,死亡2例,维持蛋白尿状态2例。表明肾组织病理变化严重,是难治与死亡率高的基础。另提示难治病例多合并高凝状态,治疗过程使用抗凝药不可忽视。 Report 7 cases of primary refractory glomerular disease, clinical treatment of recent results are not satisfied. Renal biopsy results of mesangial hyperplasia and focal segmental sclerosing nephritis in 2 cases, diffuse hyperplasia, membranous nephritis and crescentic glomerulonephritis in 1 case, so far after 5 years follow-up results cured 3 cases, 2 patients died, maintain proteinuria State 2 cases. The pathological changes of kidney showed serious, which is the basis of refractory and high mortality. Another prompt refractory cases with hypercoagulable state, the use of anticoagulants during the treatment can not be ignored.