外周T细胞淋巴瘤(PTCLs)是一种恶性度很高的肿瘤,死亡率高,疗效欠佳,需要寻求新的治疗方法,其中抑制酪氨酸蛋白激酶(PTK)活性可能是新的靶标。Syk是一种广泛存在于多种造血细胞的酪氨酸蛋白激酶,通过525/526位酪氨酸残基磷酸化激活参与细胞的生长、增殖和凋亡。最新研究显示一 Peripheral T-cell lymphoma (PTCLs) is a highly malignant tumor with high mortality and poor curative effect. It is necessary to find new treatment methods, of which inhibition of tyrosine kinase activity may be a new target. Syk is a tyrosine kinase that is widely found in many hematopoietic cells and is involved in the growth, proliferation and apoptosis of cells through the phosphorylation of tyrosine residue 525/526. The latest research shows one