牙周病是发生在牙体周围支持组织的一种慢性炎性破坏性疾病,其特点是渐进性地破坏牙周支持组织直至牙体脱落。目前,牙周组织再生术研究较为广泛的是组织工程技术,其中又以生长因子的适量和适时传递尤为重要。本文就牙周组织再生术中生长因子控释技术的装载战略和控释技术的应用等研究进展作一综述。 Periodontal disease is a chronic, inflammatory, and destructive disease that occurs in supporting tissues around the tooth and is characterized by progressive destruction of periodontal support until the tooth falls off. At present, the study of periodontal tissue regeneration is more extensive tissue engineering technology, of which the appropriate amount of growth factors and timely delivery is particularly important. This article reviews the research progress of the loading strategy of controlled release of growth factors in periodontal tissue regeneration and the application of controlled release technology.