肿瘤转移除决定于肿瘤本身的特性外,还与宿主因素如肿瘤的接种部位,宿主体液平衡和血凝特征的改变,以及单核巨噬细胞系统的功能状态等有关。近年来的研究还表明,宿主的免疫防御机能也能影响肿瘤转移的发生。本研究的目的在于探讨全身照射所致的小鼠免疫功能损伤对B_(16)黑色素瘤肺部转移的影响。现将初步结果小结如下。 Tumor metastasis is not only determined by the characteristics of the tumor itself, but also related to host factors such as the site of tumor inoculation, changes in host fluid balance and hemagglutination characteristics, and the functional status of monocyte-macrophage system. Recent studies have also shown that the host’s immune defense function can also affect the occurrence of tumor metastasis. The purpose of this study was to investigate the effect of systemic irradiation on immune metastasis in mice with B_(16) melanoma lung metastases. The preliminary results are summarized below.