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目的 :探讨影响喉癌预后的相关因素。方法 :采用免疫组化检测 96例喉鳞状细胞癌标本表达情况 ,并结合临床和病理资料分析喉癌预后因素。结果 :nm2 3、Cath- D和 CD44的阳性表达率分别为45 .7% (43/94)、5 2 .1 % (5 0 /96 )和 41 .7% (40 /96 )。喉癌部位、大小、分化程度、T分期及 nm2 3表达与喉癌颈淋巴结转移有关 (P <0 .0 5 ) ;喉癌的部位、大小、分化程度、分期及颈淋巴结转移与术后 3年生存率有关 (P<0 .0 5 )。结论 :检测 nm2 3在喉癌中表达情况 ,对预测喉癌颈淋巴结转移有一定的参考价值 ;喉癌部位、大小、分化程度、分期及颈淋巴结转移是影响术后生存率的主要因素
Objective: To investigate the related factors that affect the prognosis of laryngeal cancer. Methods: The expression of 96 samples of laryngeal squamous cell carcinoma was detected by immunohistochemistry. The prognosis of laryngeal carcinoma was analyzed by clinical and pathological data. Results: The positive expression rates of nm23, Cath-D and CD44 were 45.7% (43/94), 52.1% (50/96) and 41.7% (40/96), respectively. The location, size, differentiation degree, T stage and nm23 expression of laryngeal carcinoma were correlated with cervical lymph node metastasis of laryngeal carcinoma (P <0.05). The location, size, degree of differentiation, staging and cervical lymph node metastasis of laryngeal carcinoma were correlated with postoperative 3 Annual survival rate (P <0. 05). Conclusion: Detecting the expression of nm23 in laryngeal carcinoma has certain reference value for predicting cervical lymph node metastasis of laryngeal carcinoma. The location, size, degree of differentiation, staging and cervical lymph node metastasis of laryngeal carcinoma are the main factors affecting the postoperative survival rate