目的探讨经眼睑入路切除部分累及中颅底肿瘤的微侵袭手术方式。方法在5例尸头解剖基础上,按照文献描述熟悉相关解剖关系。在改良部分入路方式后,采用经眼睑入路微侵袭手术方式对3例前中颅底脑膜瘤患者进行治疗。部分新的手术改进包括:①将切口略下移,呈类似双重睑手术切口;②皮下游离骨膜和颞肌筋膜瓣,以修补和重建颅底;③利用神经内镜和虚拟现实技术等辅助技术,进行多技术融合手术。结果 3例脑膜瘤患者手术均达到肿瘤全切除。其中1例为鞍结节脑膜瘤,1例为侵犯眼眶的蝶骨嵴脑膜瘤,1例为蝶骨嵴内侧型脑膜瘤。3例患者随访超过1年,手术效果良好,无肿瘤复发,术后恢复好。1例患者因肿瘤侵犯眼眶,后遗有眶尖综合征。结论经眼睑入路是一种安全的手术入路,适用于中小型蝶骨嵴内侧型脑膜瘤治疗,部分累及前、中颅底的肿瘤,可以达到常规翼点入路手术效果,同时减少手术创伤并取得良好的外观。 Objective To investigate the microinvasive surgical methods of partial removal of mid-skull base tumors by eyelid approach. Methods Based on 5 cases of cadaver head anatomy, familiar with the anatomic relationship according to the literature description. After improving some of the ways, using eyelid microinvasive surgical approach to the treatment of three cases of anterior midbrain meningioma. Some of the new surgical improvements include: (1) the incision is slightly moved down, resembling a double eyelid incision; (2) the subcutaneous free periosteum and temporal myofascial flap are used to repair and reconstruct the skull base; (3) the use of neuroendoscopy and virtual reality techniques Technology, multi-technology integration surgery. Results All three cases of meningioma surgery achieved tumor resection. One case was saddle nodular meningioma, one case was sphenoid ridge meningioma orbital sphenoid ridge meningioma, and one case was sphenoidal ridge meningioma. Three patients were followed up for more than 1 year, the operation effect is good, no tumor recurrence, postoperative recovery is good. One patient had orbital apex syndrome due to tumor invasion of the orbit. Conclusion The eyelid approach is a safe surgical approach. It is suitable for the treatment of medial and lateral sphenoid ridge meningiomas. Some of them involve the tumors of the anterior and middle cranial base, which can achieve the effect of conventional pterional approach and reduce the operation Trauma and get a good appearance.