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目的:联合应用压力测定法和阻抗测定法,阐释胃食管反流症(GER)的发病机制,并探讨其与胃排空(GE)以及体位的关联性。方法:采用一种微压力/阻抗联合装置,检查10名健康早产儿(胎龄35-37周)。根据阻抗来确证GER发作,阐释GER触发机制以及GER 间隔。利用碳13标记的辛酸钠呼吸试验,确定GE状况。结果:共记录GER发作89次,其中,74%为液体反流,14%为气体反流,12%为混合物反流。暂时性低位食管括约肌松弛(TLESR)是导致反流的最主要发生机制,
OBJECTIVE: To investigate the pathogenesis of gastroesophageal reflux disease (GER) and to investigate its relationship with gastric emptying (GE) and body position in combination with pressure and impedance assays. METHODS: Ten healthy preterm infants (gestational age 35-37 weeks) were examined using a micro-pressure / impedance combination. Confirm GER attack based on impedance, explain GER triggering mechanism, and GER interval. Carbon isotope-labeled sodium octanoate breath test was used to determine GE status. RESULTS: A total of 89 episodes of GER were recorded, of which 74% were fluid reflux, 14% gas reflux, and 12% reflux. Temporary low esophageal sphincter relaxation (TLESR) is the most important mechanism leading to reflux,