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目的探讨社会支持及年龄、病情对住院老年患者淋巴细胞亚群的影响。方法应用社会支持评定量表及流式细胞仪,对225例住院老年男性患者进行调查。结果 T淋巴细胞(CD3+)与年龄呈负相关,自然杀伤细胞(CD56+)与年龄呈正相关,CD3+、辅助T淋巴细胞(CD4+)、CD56+、B淋巴细胞(CD19+)、淋巴细胞(Lc)与病情相关(P<0.05);多因素逐步回归分析:主观支持进入CD4+、Lc的逐步回归方程;主观支持的家庭成员项进入CD4+、主观支持的同事项进入CD19+、主观支持的朋友项进入Lc的逐步回归方程;社会支持利用的烦恼倾诉项进入CD3+、CD4+的逐步回归方程。结论年龄、病情与CD3+、CD4+、CD19+、CD56+相关,社会支持可能与住院老年患者的CD4+、CD19+等淋巴细胞亚群有关,烦恼倾诉能提高患者的CD3+、CD4+淋巴细胞亚群水平。
Objective To investigate the influence of social support, age and condition on the lymphocyte subsets of hospitalized elderly patients. Methods The social support rating scale and flow cytometry were used to investigate 225 hospitalized elderly male patients. Results T lymphocytes (CD3 +) were negatively correlated with age. Natural killer cells (CD56 +) were positively correlated with age. CD3 +, T lymphocytes (CD4 +), CD56 +, CD19 +, Lc (P <0.05). The multivariate stepwise regression analysis showed that the subjective support entered the stepwise regression equation of CD4 + and Lc, the subjectively supported family members entered the CD4 +, subjectively supported co-workers entered the CD19 +, the subjectively supported friends entered the Lc gradually Regression equation; social support to use the trouble to talk to enter the CD3 +, CD4 + stepwise regression equation. Conclusions The age and condition are related to CD3 +, CD4 +, CD19 + and CD56 +. Social support may be related to lymphocyte subsets such as CD4 +, CD19 + and so on in hospitalized elderly patients. Troubles and confusion can increase the level of CD3 + and CD4 + lymphocyte subsets.