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目的:探讨布拉酵母菌对早产儿黄疸的预防效果,以指导临床应用。方法:将我院2011年1月至2013年1月收治的胎龄28~32周的病情稳定、无消化道疾病的106例早产儿,随机分为观察组55例和对照组51例。观察组予以早产儿配方奶加布拉酵母菌100 mg/(kg·d)口服,对照组单纯早产儿配方奶喂养,连续治疗2~4周至校正胎龄34周,观察两组患儿黄疸及并发症发生情况。结果:观察组患儿黄疸出现时间、持续时间及消退时间分别为(4.25±1.18)d、(5.12±1.39)d及(8.56±2.04)d,对照组分别为(2.09±0.98)d,(11.25±1.68)d及(14.21±3.58)d,两组比较差异有统计学意义(P<0.05)。观察组患儿出生后第1天血清胆红素水平与对照组比较差异无统计学意义,但出生后第3天和第7天血胆红素水平与对照组比较差异有统计学意义(P<0.05)。观察组患儿腹胀、喂养不耐受及呼吸暂停发生率均低于对照组(P<0.05)。结论:口服布拉酵母菌対早产儿黄疸可起到良好的防治作用,效果显著。
Objective: To investigate the preventive effect of Saccharomyces boulardii on jaundice in premature infants to guide the clinical application. Methods: From January 2011 to January 2013 in our hospital, patients with stable gestational age of 28 to 32 weeks and without digestive diseases in our hospital from January 2011 to January 2013 were randomly divided into observation group (55 cases) and control group (51 cases). The observation group was given premature infant formula Gabora yeast 100 mg / (kg · d) orally, the control group of pure preterm infant formula feeding, continuous treatment of 2 to 4 weeks to corrected gestational age of 34 weeks, observed two groups of children with jaundice and Complications of the situation. Results: The incidence, duration and regression time of jaundice in observation group were (4.25 ± 1.18) d and (5.12 ± 1.39) days and (8.56 ± 2.04) days, respectively, and those in control group were (2.09 ± 0.98) and 11.25 ± 1.68) d and (14.21 ± 3.58) d, respectively. There was significant difference between the two groups (P <0.05). The level of serum bilirubin in observation group was no significant difference compared with control group on the first day after birth, but the level of serum bilirubin on the 3rd and 7th day after birth was significantly lower than that of the control group (P <0.05). Children in observation group had lower abdominal distension, feeding intolerance and apnea incidence than those in control group (P <0.05). Conclusion: Premature infant jaundice can play a good role in prevention and treatment, and the effect is obvious.