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在9～11孕周取绒毛标本进行染色体检查的249例高龄孕妇和在≥18孕周经羊水穿刺遗传学检查诊为有非整倍体胎儿的20例孕妇均取血测定hCG和α-hCG,进行产前诊断阳性率的评价。促性腺激素值以正常妊娠中值的倍数(MoM)表示。 hCG测定结果:249例中6例为21三体,1例为三倍体,2例平衡易位。6例21三体的平均hCG水平为114.4IU/ml,正常妊娠者为100.7IU/ml,二者无显著差别。20例中期妊娠发现非整倍体胎儿者包括13例21三体、2例18三体、2例13三体、
Twenty-nine pregnant women with chromosomes from 9 to 11 weeks of gestation and 20 pregnant women with aneuploid fetuses diagnosed with amniocentesis at ≥18 gestational weeks were tested for hCG and α-hCG , The positive rate of prenatal diagnosis evaluation. Gonadotropin values are expressed as a multiple of normal median pregnancy (MoM). Results of hCG assay: In 249 cases, 6 cases were trisomy 21, 1 case triploid and 2 cases balanced translocation. The average hCG level of trisomy 21 was 114.4 IU / ml in 6 cases and 100.7 IU / ml in normal pregnancy, with no significant difference between the two groups. Twenty cases of aneuploid fetuses in the second trimester were 13 trisomy 21, 2 trisomy 18, 2 trisomy 13,