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病毒融合蛋白可以分为三种类型,不同类型的病毒融合蛋白的结构差异很大,但是会采用相似的“发卡”构象实现融合.在一定条件下,病毒融合蛋白的疏水结构域,融合环或融合肽插入靶膜中,通过其自身折叠形成发卡使病毒和宿主的膜靠近.与此同时,融合蛋白构象变化会释放出足够的能量将双方膜打破并完成融合.本文中,我们总结了三种类型病毒融合蛋白的特征,并对其中央发卡三聚体结构域、跨膜结构域以及近膜结构域在融合过程中的作用进行了论述.
Viral fusion proteins can be divided into three types, different types of virus fusion protein structure is very different, but will use a similar “hairpin ” conformation fusion. Under certain conditions, the virus fusion protein hydrophobic domain fusion The loop or fusion peptide is inserted into the target membrane, forming a hairpin by its own folding to bring the virus and host membranes closer together. At the same time, the conformational changes of the fusion protein release enough energy to break both membranes and complete the fusion.In this paper, we conclude The characteristics of the three types of viral fusion proteins were discussed, and the role of the central issuance trimer domain, the transmembrane domain and the proximal membrane domain in the process of fusion was discussed.