Objective: To investigate the effect of preemptive analgesia withflurbiprofen axetil injection on the analgesic effect, inflammatory response, stress response and immune response in patients undergoing thoracoscopic lobectomy. Methods: 92 patients with early non-small cell lung cancer who underwent thoracoscopic lobectomy from January 2016 to March 2018 in our hospital were divided into observation group and control group according to the method of random digital table, 46 cases in each group. The control group was given routine perioperative analgesia, the observation group was given advanced analgesia mode, and the visual simulation scoring method (visual) was used to observe the patients in the two groups at 4, 12, 24 and 48 h after operation The results showed that the level of inflammation factor, stress response factor and immune response were significantly higher than that of before operation (T0), when anesthesia woke up (T1), 12 hours after operation (T2), 24 h after operation (T3) and 48 h after operation (T4). Results: (1) The VAS score of the observation group was significantly lower than that of the control group (P<0.05) at 4, 12, 24 and 48 h after operation; (2) The levels of IL-6, IL-10, SP-A and TNF-α in the two groups were significantly lower than that of the control group (P<0.05) The level of factor-α, TNF-α) was higher than that of to time point, and showed an upward trend;the level of IL-6, IL-10, TNF-α, SP-A decreased gradually at T3, T4 time points, the level of IL-6, TNF-α, SP-A in T1, T2, T3, T4 time points in the observation group was lower than that of the control group, and the level of IL-10 was higher than that of the control group (P<0.05); (3) Compared with T0 time point, the epinephrine (EPIPH) at T1, T2, T3, T4 time points in the two groups The levels of rine, e, noradrenaline, NE and cortisol in the observation group increased first and then decreased;the levels of E, NE and cor in the observation group were lower than those in the control group at T1, T2, T3 and T4 time points (P<0.05);and (4) Compared with T0 time point, the serum IgG, IgM and IgA levels in the two groups decreased gradually at T1, T2, T3 and T4 time points, but the observation group The levels of IgG, IgM and IgA in serum of group A were higher than those of group B (P<0.05). Conclusion: Preemptive analgesia with flurbiprofen axetil injection can significantly improve the postoperative pain, reduce the level of inflammation, reduce the stress response and increase the level of immune response.