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癌细胞与细胞外基质(ECM)之间的相互作用是肿瘤浸润和转移的一个重要环节,这种相互作用是由存在于细胞膜上的一大类细胞粘附分子(CAMs)来介导的[1]。CAMs不仅参与调节正常细胞的生物学行为,而且对肿瘤细胞的浸润和转移有着重要的影响。根据免疫球蛋白超基因家族中的CD44分...
The interaction between cancer cells and the extracellular matrix (ECM) is an important part of tumor invasion and metastasis, and this interaction is mediated by a large class of cell adhesion molecules (CAMs) present on the cell membrane [ 1]. CAMs are not only involved in regulating the biological behavior of normal cells, but also have an important effect on the invasion and metastasis of tumor cells. According to immunoglobulin super gene family of CD44 ...