难治性原发性肾病综合征(PNS)一般泛指用强的松(P)1.5～2mg/kg·d治疗8周无效、频繁复发以及激素依赖的病例,除与肾病的类型有关外,多与开始治疗不正规有关。现就其治疗分述于下。 激素治疗 足量分次服效果较顿服好;隔日清晨服优于间歇疗法;中长程疗法优于2～3个短疗程。 Refractory primary nephrotic syndrome (PNS) generally refers to the use of prednisone (P) 1.5 ~ 2mg / kg · d treatment for 8 weeks ineffective, frequent recurrence and hormone-dependent cases, in addition to the type of kidney disease, More and start treatment is not formal. The treatment is now divided in the next. Hormone therapy adequate sub-sub-service effect than Dayton good; early morning service better than intermittent therapy; medium-long-term therapy is better than 2 to 3 short courses.