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目的采用Meta分析评价双歧杆菌三联活菌胶囊/散治疗儿童功能性便秘的临床疗效。方法检索中国知网、万方、维普、Pubmed、Embase、Web of Science数据库,检索时限均从建库至2015年12月,收集国内外应用双歧杆菌三联活菌胶囊/散治疗儿童功能性便秘的所有随机对照试验(randomized controlled trial,RCT)和前瞻性非随机对照试验(non-randomized controlled trial,non-RCT),纳入文献时间从2005年1月至2013年12月。按照纳入与排除标准选择文献,进一步提取纳入研究的资料并评价其方法学质量后,采用Cochrane协作网提供的RevMan 5.2软件进行Meta分析。结果检索文献无RCT研究,纳入9个前瞻性non-RCT研究,合计673例患者,其中治疗组(对照组常规治疗+双歧杆菌三联活菌胶囊/散)345例,对照组328例。Meta分析结果显示:治疗组的治疗有效率优于对照组[OR=4.81,95%CI=(2.32,9.97),P<0.0001];治疗组儿童功能性便秘复发率低于对照组[OR=0.19,95%CI(0.05,0.68),P=0.01]。结论双歧杆菌三联活菌胶囊/散与常规治疗药物联用可以提高儿童功能性便秘的总体疗效,同时可以有效降低儿童功能性便秘的复发率。
Objective To evaluate the clinical efficacy of Bifidobacterium triple viable capsule / powder in the treatment of children with functional constipation by Meta-analysis. Methods The databases of CNKI, Wanfang, Weipu, Pubmed, Embase and Web of Science were retrieved from the database to December 2015. The domestic and international application of Bifidobacterium triple viable capsule / All randomized controlled trials (RCTs) and non-randomized controlled trials (non-RCTs) were included in the literature from January 2005 to December 2013. Meta-analysis was performed using the RevMan 5.2 software provided by the Cochrane Collaboration after selecting the literature according to inclusion and exclusion criteria, further extracting the data from the studies and assessing the quality of the methodology. Results There were no RCTs in the retrieved articles, and 9 prospective non-RCT studies were included in the literature. A total of 673 patients were enrolled. Among them, 345 patients in the treatment group (conventional treatment of Bifidobacterium triple active viable capsule / powder) and 328 in the control group. The results of Meta analysis showed that the effective rate of treatment in the treatment group was superior to that of the control group [OR = 4.81, 95% CI = (2.32, 9.97), P <0.0001]. The recurrence rate of functional constipation was lower in the treatment group than in the control group [OR = 0.19, 95% CI (0.05, 0.68), P = 0.01]. Conclusion Bifidobacterium triple viable capsule / powder combined with conventional therapeutic drugs can improve the overall efficacy of functional constipation in children, and can effectively reduce the recurrence rate of functional constipation in children.