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目的探讨尿钠排泄量与大小动脉弹性指数(C1,C2)的关系。方法入选体检人群397例(男性195例,女性202例),年龄(53.4±15.1)岁。通过24 h尿钠排泄量测定钠盐摄入量,将入选人群分为低盐组(n=99),低中盐组(n=100),中高盐组(n=99),高盐组(n=99)。C1、C2采用CVProfilor Do-2020动脉脉搏波分析仪测量。使用广义线性模型比较24 h尿钠排泄量与C1、C2的关系,使用多元线性回归分析影响C1、C2的主要因素。结果随着24 h尿钠排泄量的增多,C1、C2逐步降低,其中高盐组较低盐组C1、C2显著降低。多元逐步线性回归分析结果提示24 h尿钠排泄量增高是C1、C2降低的独立危险因素。结论随着24 h尿钠排泄量的增加,反映动脉弹性的指标C1、C2下降。
Objective To investigate the relationship between urinary sodium excretion and arterial elasticity index (C1, C2). Methods 397 cases (195 males and 202 females) were enrolled in the physical examination group and were (53.4 ± 15.1) years old. The sodium intake was measured by 24 h urinary sodium excretion, and the subjects were divided into low salt group (n = 99), low salt group (n = 100), medium high salt group (n = 99) (n = 99). C1, C2 were measured using a CVProfilor Do-2020 arterial pulse wave analyzer. The relationship between 24 h urinary sodium excretion and C1, C2 was compared using the generalized linear model. Multiple linear regression analysis was used to analyze the main factors influencing C1 and C2. Results With the increase of 24 h urinary sodium excretion, C1 and C2 gradually decreased, among which, C1 and C2 of the high salt group were significantly lower than those of the low salt group. Multivariate stepwise linear regression analysis indicated that 24-hour increase of urinary sodium excretion was an independent risk factor for reduction of C1 and C2. Conclusions With the increase of 24 h urinary sodium excretion, the indexes C1 and C2 that reflect arterial elasticity decline.