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阐述细胞浆钙浓度变化所介导的效应在哮喘病理生理中的作用,并讨论钙通道阻滞剂对哮喘患者的治疗机制。对同时有高血压、冠心病的哮喘患者,应用钙通道阻滞剂以取代β-肾上腺素阻滞剂和血管紧张素转换酶抑制剂是适宜的和安全的。
The effects of changes in cytosolic calcium concentration on the pathophysiology of asthma were elucidated. The therapeutic mechanism of calcium channel blockers in asthmatic patients was also discussed. It is appropriate and safe to use calcium channel blockers to replace β-adrenergic blockers and angiotensin-converting enzyme inhibitors in patients with asthma who have both hypertension and coronary heart disease.