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目的：评价米安舍林治疗脑卒中后抑郁症的临床疗效。方法入选我院住院的脑卒中后抑郁症患者100例，随机分成试验组和对照组，各50例。试验组口服米安舍林，初始剂量15 mg? d－1，1周后加至60 mg? d－1；对照组口服阿米替林，初始剂量30 mg? d－1，1周后加至150 mg? d－1，疗程均为8周。比较2组治疗前和治疗后的2，4，6，8周末的汉密尔顿抑郁量表（ HAMD）、副反应量表（TESS）、日常生活指数（ADL）评分。结果试验组和对照组总有效率分别为86．0％和78．0％，差异无统计学意义（ P＞0．05）。2组患者治疗结束后HAMD评分均较治疗前显著下降，并且均随治疗时间延长逐步下降，但2组间差异无统计学意义（ P＞0．05）。2组患者的TESS评分在治疗各期差异均有统计学意义（P＜0．01）。2组患者治疗结束后ADL评分均较治疗前显著升高（P＜0．01）。结论米安舍林可较快缓解脑卒中后抑郁症患者的焦虑状况，并促进其功能有效康复。“,”Objective To evaluate the clinical efficacy of mianserin on post-stroke depression.Methods A total of 100 patients were random-ly selected and divided into treatment group ( 50 patients ) and control group ( 50 patients ) according to simple random sampling.Patients in treatment group were treated with mianserin ( the initial dose was 15 mg? d-1 , and 1 week later the dose was added to 60 mg? d-1 ) and those in control group with amitriptyline ( the initial dose was 30 mg? d-1 , and 1 week later the dose was added to 150 mg? d-1 ) .The data of hamilton depression scale(HAMD), treatment emergent symptom scale(TESS) and activities of daily living(ADL) were assessed before treat-ment and 2, 4, 6 and 8 weeks after the treatment.Results The markedly effective rate in treatment group and control group were 86.0%and 78.0%, but the difference was not statistical different ( P >0.05 ) .The data of HAMD scores in two groups were both decreased compared with before treat-ment, but without statistical difference (P>0.05), the difference of TESS scores during the treatment were all significant in two groups (P<0.01). Conclusion Mianserin can relieve the anxiety of patients with post-stoke depression quickly and promote their function to be recovered effectively.