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目的:探讨泮托拉唑、阿莫西林与甲硝唑三联疗法对胃溃疡患者疗效的影响。方法:选取2012年10月至2015年11月韶关市铁路医院确诊治疗的胃溃疡患者60例,依据随机分配原则分为三联组和对照组,每组30例,对照组患者给予泮托拉唑、阿莫西林联合治疗,三联组患者给予泮托拉唑、阿莫西林与甲硝唑三联疗法治疗,比较两组患者治疗效果和不良反应发生情况。结果:三联组和对照组患者治疗有效率分别为93.33%、73.33%,前者明显高于后者,差异具有统计学意义(P<0.05);三联组和对照组患者不良反应发生率分别为16.67%、10.00%,两组比较,差异无统计学意义(P>0.05)。结论:泮托拉唑、阿莫西林与甲硝唑三联疗法可有效提高胃溃疡的临床疗效,且具有良好的安全性。
Objective: To investigate the effect of pantoprazole, amoxicillin and metronidazole triple therapy on the efficacy of gastric ulcer patients. Methods: From October 2012 to November 2015, 60 patients with gastric ulcer diagnosed and treated in Shaoguan Railway Hospital were divided into triple group and control group according to the principle of random distribution, 30 cases in each group. Patients in the control group were treated with pantoprazole , Amoxicillin combination therapy, triple group patients were given pantoprazole, amoxicillin and metronidazole triple therapy, the treatment effect and adverse reactions were compared between the two groups. Results: The effective rates of triple therapy group and control group were 93.33% and 73.33% respectively, the former was significantly higher than the latter (P <0.05). The incidences of adverse reactions in triple therapy group and control group were 16.67 %, 10.00% respectively. There was no significant difference between the two groups (P> 0.05). Conclusion: Pantoprazole, amoxicillin and metronidazole triple therapy can effectively improve the clinical efficacy of gastric ulcer, and has good safety.