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目的:探讨扎鲁司特联合舒利迭治疗儿童支气管哮喘的疗效及对肺功能的影响。方法:选取2010年6月~2013年10月江门市新会区人民医院收治的104例支气管哮喘患儿,将患儿随机分为观察组及对照组,每组各52例。在常规治疗的基础上,对照组加用舒利迭吸入治疗,观察组采取舒利迭与扎鲁司特联合治疗。评定两组患儿的治疗效果及治疗前后的肺功能情况并进行统计学分析。结果:观察组与对照组的总有效率分别为90.38%和71.16%,观察组显著高于对照组,差异有统计学意义(P<0.05);治疗后,观察组和对照组的1 s用力呼气容积(FEV1)(实测值∕预计值)分别为(72.83±10.77)%和(63.28±10.24)%,观察组明显高于对照组,差异有统计学意义(P<0.05);观察组的峰值呼气流速(PEF)(实测值∕预计值)为(69.24±9.93)%,明显高于对照组〔(59.86±10.05)%〕,差异有统计学意义(P<0.05)。结论:舒利迭与扎鲁司特联合治疗儿童支气管哮喘在缓解临床症状、提高治疗效果及改善肺功能等方面具有显著的优越性。
Objective: To investigate the efficacy of zafirlukast combined with seretide in children with bronchial asthma and its effect on lung function. Methods: From June 2010 to October 2013, 104 children with bronchial asthma admitted to Xinmin District People’s Hospital of Jiangmen City were randomly divided into observation group and control group, with 52 cases in each group. On the basis of routine treatment, the control group was treated with seretide inhalation, and the observation group was treated with seretide and zalutide. The therapeutic effect of two groups of children and the lung function before and after treatment were evaluated and statistically analyzed. Results: The total effective rates of the observation group and the control group were 90.38% and 71.16%, respectively, the observation group was significantly higher than the control group (P <0.05); after treatment, the force of 1 s in the observation group and the control group The expiratory volume (FEV1) was (72.83 ± 10.77)% and (63.28 ± 10.24)%, respectively. The observation group was significantly higher than that of the control group (P <0.05) The peak expiratory flow rate (PEF) was (69.24 ± 9.93)%, which was significantly higher than that in the control group (59.86 ± 10.05%). There was significant difference between the two groups (P <0.05). Conclusion: The combination of seretide and zafirlukast in children with bronchial asthma has obvious advantages in relieving clinical symptoms, improving the therapeutic effect and improving lung function.