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目的:分析比较125I粒子植入近距放疗联合间歇性内分泌治疗在前列腺癌治疗中的效果。方法:回顾2001年1月～2011年2月期间未接受根治性前列腺切除而接受治疗满5年的147例前列腺癌患者,按治疗方式分为三组;A组43例单纯采用间歇性内分泌治疗;B组31例单纯采用近距离125I粒子植入;C组73例施行近距离125I粒子植入+间歇性内分泌治疗。比较三组患者的临床症状、PSA变化情况、局部进展率、无事件生存率。结果:147例患者,A组5年生存率为88.37%,无效率13.95%,无事件生存率16.28%;B组生存率为90.32%,无效率22.58%,无事件生存率32.26%;C组生存率为90.41%,无效率6.85%,无事件生存率34.25%。结论:近距离125I粒子植入+间歇性内分泌联合治疗作为前列腺癌的综合治疗手段,可以提高无事件生存率、增加治疗有效率、缩短内分泌治疗时间。
OBJECTIVE: To analyze the effects of 125I seeds brachytherapy combined with intermittent endocrine therapy in the treatment of prostate cancer. Methods: A total of 147 patients with prostate cancer who underwent radical prostatectomy without treatment for radical prostatectomy for 5 years between January 2001 and February 2011 were retrospectively divided into three groups according to the mode of treatment. A group of 43 patients received intermittent endocrine therapy ; Group B 31 patients with simple 125I seed implantation; Group C 73 patients with 125I seed implantation + intermittent endocrine therapy. The clinical symptoms, changes of PSA, local progression rate and event-free survival were compared among the three groups. Results: In the 147 patients, the 5-year survival rate was 88.37%, the inefficiency rate was 13.95%, the event-free survival rate was 16.28% in group A; the survival rate in group B was 90.32%, the inefficiency rate was 22.58%, and the event-free survival rate was 32.26% Survival rate was 90.41%, inefficiency 6.85%, event-free survival rate 34.25%. Conclusion: 125I seeds implantation combined with intermittent endocrine therapy as a comprehensive treatment of prostate cancer can increase the event-free survival rate, increase the treatment efficiency and shorten the time of endocrine therapy.