Objective:To find out the in vitro antipalsmodial activities of mangrove leaf extracts.Methods: In vitro antiplasmodial assay was carried out with 13 different mangrove plants.Column chromatography was performed with the most potent Agecerious corniculatum(A.corniculatum) by using various solvent extractions.GC-MS was also preformed with the most potent ethanolic fraction of the A.corniculatum extract.Results:Of the 13 mangroves plants, A.corniculatum showed maximum percentage of parasitemia suppression(94.98±1.16)%.Column chromatography was performed with A.corniculatum with different solvents and the methanolic extract showed maximum percentage(99.73±1.63)%of parasitemia inhibition at 150μg/mL concentration with the IC_(50) value of(29.28±3.23)μg/mL concentration.The results of the GC-MS analysis observed that,the most potent methanolic extract showed maximum retention time(30.687 RT) and the chemical class was identified as Spiro[benzofuran-2(3 H),1’-(3 cyclohexane)-2’,3- dione,7-chloro-4’,6]which was responsible for the antiplasmodial activity.Conclusions:It is concluded from the present study that,the chemical constituents of A.corniculatum collected from Pichavaram mangrove forest can be used as a putative antiplasmodial drugs in future. Objective: To find out the in vitro antipalsmodial activities of mangrove leaf extracts. Methods: In vitro antiplasmodial assay was carried out with 13 different mangrove plants. Columns chromatography was performed with the most potent Agecerious corniculatum (A.corniculatum) by using various solvent extractions .GC-MS was also preformed with the most potent ethanolic fraction of the A.corniculatum extract. Results: Of the 13 mangroves plants, A.corniculatum showed maximum percentage of parasitemia suppression (94.98 ± 1.16)%. Column chromatography was performed with A .corniculatum with different solvents and the methanolic extract showed maximum percentage (99.73 ± 1.63)% of parasitemia inhibition at 150 μg / mL concentration with the IC 50 value of (29.28 ± 3.23) μg / mL concentration.The results of the GC- MS analysis observed that, the most potent methanolic extract showed maximum retention time (30.687 RT) and the chemical class was identified as Spiro [benzofuran-2 (3H), 1 ’- (3 cyclohexane) -2’, 3- dione , 7-chloro-4 ’, 6] which was responsible for the antiplasmodial activity. Conclusions: It is concluded from the present study that, the chemical constituents of A.corniculatum collected from Pichavaram mangrove forest can be used as a putative antiplasmodial drugs in future.