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目的 观察卡托普利对糖尿病合并肺结核患者应用氨基糖甙类药物时对肾脏的保护作用。方法 85例糖尿病合并肺结核患者 ,随机分为治疗组 ( 44例 )与对照组 ( 41例 )。两组抗痨方案均含氨基糖甙类药物。治疗组在 2个月强化治疗期间加服卡托普利。治疗前及强化治疗结束时检测尿微量白蛋白、β2 —微球蛋白、血清肌酐及肌酐清除率并进行比较。结果 治疗组 β2 -微球蛋白较治疗前显著降低 (P <0 .0 5) ,其余各项指标无明显变化。对照组尿微量白蛋白和 β2 -微球蛋白显著增加 (P <0 .0 1 ,P <0 .0 5)。结论 卡托普利对长期应用氨基糖甙类药物患者的肾脏有一定的保护作用。
Objective To observe the protective effect of captopril on the kidneys when using aminoglycosides in diabetic patients with pulmonary tuberculosis. Methods A total of 85 diabetic patients with pulmonary tuberculosis were randomly divided into treatment group (44 cases) and control group (41 cases). Two anti-tuberculosis programs contain aminoglycosides. The treatment group received captopril during the 2-month intensive treatment. Urine microalbumin, β2 - microglobulin, serum creatinine and creatinine clearance were measured before treatment and at the end of intensive treatment and compared. Results The β2 - microglobulin in the treatment group was significantly lower than that before treatment (P <0.05), while the other indexes did not change significantly. Urine microalbumin and β2 - microglobulin in the control group increased significantly (P <0.01, P <0.05). Conclusions Captopril has a protective effect on the kidneys of patients with long-term use of aminoglycosides.