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目的了解深圳市急性呼吸道感染儿童WU多瘤病毒(WU polyomavirus,WUPoyV)感染特点及临床特征。方法收集深圳市两家医院急性呼吸道感染住院儿童咽拭子或鼻咽分泌物标本,采用PCR检测WUPoyV及9种常见呼吸道病毒,分析WUPoyV感染特点及临床表现。结果共收集2 025例患儿标本(年龄15d~14岁),10种病毒至少1种阳性971例(阳性率为47.95%)。检出WUPoyV 39例,阳性率1.93%,其中26例(66.67%)为单纯WUPoyV感染,13例(33.33%)为WUPoyV与其他病毒混合感染,感染者平均年龄23.3月,92.31%的患儿<4岁。WUPoyV感染全年均有发生,3~5月为发病高峰。WUPoyV感染症状主要表现为咳嗽、喘息、发热等,X线胸片检查主要为支气管肺炎或细支气管炎表现,临床症状和体征与其他呼吸道病毒感染相似;单纯感染与混合感染症状无明显差别。结论WUPoyV感染以<4岁儿童组常见,全年均可发生;春末夏初多见,其临床表现与普通的支气管肺炎和支气管炎类似,深圳市小儿呼吸道感染可能部分与WUPoyV有关。
Objective To investigate the characteristics and clinical characteristics of WU polyomavirus (WUPoyV) infection in children with acute respiratory tract infection in Shenzhen. Methods Samples of throat swabs or nasopharyngeal secretions from hospitalized children with acute respiratory infection in two hospitals in Shenzhen were collected. WUPoyV and nine common respiratory viruses were detected by PCR. The characteristics and clinical manifestations of WUPoyV infection were analyzed. Results Totally 2 025 cases of children aged 15d to 14 years old were collected, and at least one of 10 viruses was positive (971 cases, the positive rate was 47.95%). The positive rate of WUPoyV was detected in 39 cases (1.93%). Among them, 26 cases (66.67%) were infected with WUPoyV alone and 13 cases (33.33%) were infected with WUPoyV mixed with other viruses. The mean age of infected persons was 23.3 months, 92.31% 4 years. WUPoyV infection occurred throughout the year, 3 to May peak incidence. WUPoyV infection symptoms mainly manifested as cough, wheezing, fever, etc., X-ray examination mainly for bronchial pneumonia or bronchiolitis, clinical symptoms and signs and other respiratory virus infection similar; simple infection and mixed infection symptoms no significant difference. Conclusions WUPoyV infection is common in children <4 years of age and may occur throughout the year. It is more common in late spring and early summer and its clinical manifestations are similar to those of common bronchopneumonia and bronchitis. The respiratory infection of WUPoyV may be partly related to WUPoyV in children.