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目的:探讨CyclinB1在良、恶性淋巴疾病表达差异以及在恶性淋巴瘤中表达与多种预后因素的相互关系,并分析其表达的临床意义。方法:采用免疫组织化学ABC法,检测CyclinB1在83例非霍奇金淋巴瘤(NHL)组织及20例淋巴结反应性增生(RH)组织中的表达情况。结果:CyclinB1在NHL中的表达显著高于RH组织中的表达(P<0.01);NHL中CyclinB1在Ⅲ+Ⅳ期的表达显著高于Ⅰ+Ⅱ期(P<0.05),在有结外受侵的NHL患者中明显高于无结外受侵的患者(P<0.05),在侵袭性NHL显著高于惰性NHL(P<0.05)。结论:CyclinB1可能参与NHL的进展。检测CyclinB1的表达情况,有助于NHL和RH的鉴别诊断,对判断NHL的恶性程度有一定的临床价值。
OBJECTIVE: To investigate the relationship between the expression of CyclinB1 in benign and malignant lymphoid diseases, the expression in malignant lymphoma and various prognostic factors, and to analyze the clinical significance of its expression. Methods: Immunohistochemical ABC method was used to detect the expression of CyclinB1 in 83 non-Hodgkin’s lymphoma (NHL) tissues and 20 lymph node-reactive hyperplasia (RH) tissues. Results: The expression of CyclinB1 in NHL was significantly higher than that in RH (P <0.01). The expression of CyclinB1 in stage Ⅲ + Ⅳ in NHL was significantly higher than that in stage Ⅰ + Ⅱ (P <0.05) Invaded NHL patients were significantly higher than those without extranodal invasion (P <0.05), and in aggressive NHL was significantly higher than that of inactive NHL (P <0.05). Conclusion: CyclinB1 may be involved in the progression of NHL. Detection of CyclinB1 expression, contribute to the differential diagnosis of NHL and RH, NHL to determine the degree of malignancy has some clinical value.