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目的探讨不同剂量顺式阿曲库胺在小儿手术中的麻醉效果。方法收集我院2011年3月-2013年1月手术的小儿患者100例,随机分成A组和B组各50例,A组应用顺式阿曲库胺剂量为0.10mg/kg,B组应用顺式阿曲库胺剂量为0.15mg/kg。结果 A组体内起作用时间为(40.8±4.5)min,肌松恢复时间为(11.2±1.6)min,阻滞维持时间为(17.3±2.4)min,TOF无反应时间为(15.2±2.3)min,起效时间为(116.7±10.5)min;组体内起作用时间为(52.9±3.8)min,肌松恢复时间为(12.3±1.6)min,阻滞维持时间为(26.1±2.8)min,TOF无反应时间为(21.9±2.2)min,起效时间为(112.2±7.9)min;两组体内起作用时间、阻滞维持时间、TOF无反应时间比较有显著性差异(P<0.05),肌松恢复时间和起效时间比较无显著性差异(P>0.05)。结论对于小儿手术的麻醉应用顺式阿曲库胺的剂量为0.15mg/kg,麻醉效果最佳,值得临床推广。
Objective To investigate the anesthetic effect of different doses of cisatracurium in pediatric surgery. Methods 100 cases of pediatric patients who underwent surgery in our hospital from March 2011 to January 2013 were randomly divided into group A and group B (50 cases each), group A received cisatracurium (0.10 mg / kg), group B Cisatracurium dose of 0.15mg / kg. Results The time of in vivo action in group A was (40.8 ± 4.5) min, the recovery time of muscle relaxation was (11.2 ± 1.6) min, the duration of blockade was (17.3 ± 2.4) min and the TOF nonresponse time was (15.2 ± 2.3) min , The onset time was (116.7 ± 10.5) min; the onset time in vivo was (52.9 ± 3.8) min, the recovery time of muscle relaxation was (12.3 ± 1.6) min, the maintenance time of block was (26.1 ± 2.8) min, The response time was (21.9 ± 2.2) min, and the onset time was (112.2 ± 7.9) min. There was significant difference in the active time, There was no significant difference between recovery time and onset time of pine (P> 0.05). Conclusion The dose of cisatracurium for anesthesia in pediatric surgery is 0.15mg / kg, which has the best anesthetic effect and is worthy of clinical promotion.