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选择肝硬化门脉高压患者（Ｃｈｉｌｄ－Ｐｕｇｈ 分级Ｂ级）２０ 例及健康对照者２０ 例，快速静脉注射左旋精氨酸（Ｌ－Ａｒｇ）２０ｍ ｌ，于注射前及注射后２、４、６ 分钟分别测血清胰岛素（Ｉｎｓ）、Ｃ肽（Ｃ－ｐ）和胰升糖素（Ｇｃ）水平。对照组另行葡萄糖（Ｇｌｕ）兴奋试验，方法同上。结果显示，对照组经葡萄糖和Ｌ－Ａｒｇ 刺激后２ 分钟Ｉｎｓ、Ｃ－ｐ 分泌达峰值，前者峰值虽高于后者，但无明显差异（Ｐ＞ ０．０５）。肝硬化门脉高压组空腹时Ｉｎｓ和Ｇｃ高于对照组（Ｐ均＜ ０．０５），Ｌ－Ａｒｇ 兴奋后２ 分钟两组Ｉｎｓ、Ｃ－ｐ 和Ｇｃ达峰值，门脉高压组Ｉｎｓ和Ｇｃ峰值虽高于对照组，但峰值较空腹值升高倍数却低于对照组（Ｐ均＜ ０．０５）。提示肝硬化门脉高压患者存在胰岛素抵抗、胰升糖素血症及胰岛早期储备能力下降
Twenty patients with cirrhosis and portal hypertension (20 Child-Pugh grading class B) and 20 healthy controls were enrolled in this study. Rapid intravenous injection of L-arginine (L-Arg) The levels of serum insulin (Ins), C-peptide (C-p) and glucagon (Gc) were measured respectively. Control group glucose (Glu) excitement test, method Ibid. The results showed that the secretion of Ins and C-p peaked at 2 minutes after glucose and L-Arg stimulation in the control group. The peak value of the former was higher than the latter, but there was no significant difference (P> 0.05). The Ins and Gc of patients with cirrhosis were higher than those of the control group (all P <0.05), the peak values of Ins, C-p and Gc reached the peak at 2 minutes after L-Arg excitability, while those of Ins and Gc Although the peak value was higher than that of control group, the peak value of crest value was lower than that of control group (P <0.05). Prompted the existence of patients with cirrhosis and portal hypertension insulin resistance, glucagonmia and pancreatic islet early reserve capacity decreased