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采用静电纺技术,制备了纯聚乙烯醇(PVA)和担载了不同量抗凝血药物低分子右旋糖酐(Dex-40)的载药纳米纤维膜,研究了药量对膜血液相容性的影响。借助扫描电镜(SEM)和傅里叶红外光谱仪(FT-IR)观察纤维形貌、分析膜的组分;用电子万能强力仪测试了膜的力学性能;以溶血、动态凝血实验研究了药物和药量对膜血液相容性的影响。结果表明:可纺性较好的纺丝液浓度为PVA10%、药粉1%,PVA和药粉能很好地融合在一起,载药膜的拉伸强度稍高于纯PVA膜,但断裂伸长率有所下降。添加药粉后,载药膜的溶血率低于5%,且内源性凝血因子被激活的程度低,膜的血液相容性显著改善。
Electrospun technology was used to prepare pure polyvinyl alcohol (PVA) and drug-loaded nanofibrous membranes loaded with low molecular weight dextran (Dex-40) with different amounts of anticoagulants. The effects of dosage on membrane blood compatibility influences. The morphology of the fiber was observed by means of scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR), the composition of the membrane was analyzed, the mechanical properties of the membrane were tested by electron universal strength tester, and the drug and Effect of Dose on Blood Compatibility of Membrane. The results showed that the spinnability of the spinnable spinning solution was 10% PVA and 1% powder, and PVA and powder could blend well. The tensile strength of the film was slightly higher than that of the pure PVA film, but the elongation at break The rate of decline. After adding the powder, the drug-loaded membrane has a hemolysis rate of less than 5%, and the degree of activation of the endogenous coagulation factors is low, and the blood compatibility of the membrane is remarkably improved.