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当体内维生素E血浓度<0.5mg/dl时红细胞双氧水溶血率增高。对99例出生体重在正常范围的足月产儿、66例早产儿及17例出生体重<2,500克的足月儿测定红细胞溶血率以诊断是否存在维生素E缺乏。按年龄各分四组(1～7天,8～14天,15～28天,29天～3月)进行观察,发现溶血率增高与三种因素有关:(1)多数发生在29天～3月年龄组;(2)出生体重<2,500克者多见;(3)人工喂养者多见。26例溶血率增高者红细胞数偏低,有4例出现浮肿。给出生体重<2,500克的新生儿预防性肌肉注射维生素E100毫克,于生后第二个月测定溶血率,增高人数的比例明显减少,但人工喂养者仍有部分溶血率增高,故对这类小儿的预防剂量需调整。
When the body of vitamin E blood concentration <0.5mg / dl erythrocyte hemolysis rate increased. 99 cases of full-term birth weight in the normal range of full-term infants, 66 cases of premature children and 17 cases of birth weight <2,500 grams of full-term children hematocrit determination of red blood cell hemolysis in order to diagnose the existence of vitamin E deficiency. According to age, four groups (1-7 days, 8-14 days, 15-28 days, 29 days-March) were observed. The increase of hemolysis was found to be related to three factors: (1) Most occurred in 29 days ~ March age group; (2) Birth weight <2,500 grams were more common; (3) more common artificial feeding. 26 cases of hemolysis increased the number of red blood cells is low, 4 cases of edema. Preventive intramuscular injection of 100 mg of vitamin E to newborns weighing <2,500 grams at a birth weight of 2,500 grams resulted in a significant reduction in the rate of hemolysis in the second month after birth, Prevention dose in children need to be adjusted.