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HBsAg/IgM循环复合物系于1981年发现,并初步查明该复合物可作急性乙型肝炎早期血清诊断标志和预后标志,且已逐渐用于乙型肝炎血清流行病学调查。晚近已采用ELISA法检测HBsAg/IgM,配合其它HBV标志,对乙型肝炎的发病机理与转归等将会有更深入的研究。一、HBsAg/IgM的性质与形成HBsAg/IgM的浮密度与22nm型HBsAg相似,为1.22g/cm~3(CsCL液内),其沉降速率(蔗糖液内)比游离状HBsAg快,与HBsAg/IgM复合物大小递增相一致。并可获得两个活性高峰,第一高峰复合物主要由22nmHBsAg组成,第二高峰则由丝状型HBsAg组成较大的复合物。
HBsAg / IgM circulating complex was discovered in 1981, and initially identified the compound can be used as an early diagnosis of acute hepatitis B serum markers and prognostic markers, and has been gradually used in hepatitis B serum epidemiological survey. Recently, ELISA has been used to detect HBsAg / IgM, with other HBV markers, hepatitis B pathogenesis and prognosis will have more in-depth study. First, the nature of HBsAg / IgM formation and formation of HBsAg / IgM floating density and 22nm HBsAg similar to 1.22g / cm ~ 3 (CsCL liquid), the sedimentation rate (sucrose solution) faster than free HBsAg, and HBsAg / IgM complexes in increasing size consistent. And two active peaks were obtained. The first peak complex mainly consisted of 22 nm HBsAg and the second peak consisted of filamentous type HBsAg.