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目的探讨左旋泮托拉唑钠对幽门结扎大鼠胃溃疡模型的治疗作用。方法 60只健康SD大鼠作为动物试验对象,随机分为左旋泮托拉唑钠组、泮托拉唑钠组、模型对照组,各20只。三组大鼠均进行幽门结扎建立胃溃疡模型,且术后饲养环境相同。左旋泮托拉唑钠组大鼠尾静脉注射左旋泮托拉唑钠(1.8 mg/kg),泮托拉唑钠组大鼠尾静脉注射泮托拉唑钠(1.8 mg/kg),模型对照组大鼠注射等容积的生理盐水。给药18 h后,观察大鼠胃黏膜面的溃疡情况,并比较三组溃疡指数、溃疡抑制率以及溃疡病理组织学结果。结果泮托拉唑钠组和左旋泮托拉唑钠组大鼠胃部溃疡指数显著低于模型对照组,且溃疡抑制率显著高于模型对照组,差异具有统计学意义(P<0.05);左旋泮托拉唑钠组大鼠胃部溃疡指数显著低于泮托拉唑钠组,且溃疡抑制率显著高于泮托拉唑钠组,差异具有统计学意义(P<0.05)。泮托拉唑钠组和左旋泮托拉唑钠组大鼠总溃疡发生率显著低于模型对照组,差异具有统计学意义(P<0.05);左旋泮托拉唑钠组大鼠总溃疡发生率为40.0%,显著低于泮托拉唑钠组的75.0%,差异具有统计学意义(P<0.05)。结论左旋泮托拉唑钠治疗幽门结扎大鼠胃溃疡模型的效果良好。
Objective To investigate the therapeutic effect of L-pantoprazole sodium on gastric ulcer model in rats with pylorus ligation. Methods Sixty healthy SD rats were randomly divided into L-pantoprazole sodium group, pantoprazole sodium group and model control group, 20 rats in each group. Three groups of rats were established pyloric ligation gastric ulcer model, and the same feeding environment. L-pantoprazole sodium group rats were injected with L-pantoprazole sodium (1.8 mg / kg) through tail vein, pantoprazole sodium group (1.8 mg / kg) Rats were injected with equal volume of saline. After 18 h of administration, the gastric mucosal surface ulcers in rats were observed. The ulcer index, the ulcer inhibition rate and the histopathological results of ulcer were compared among the three groups. Results The ulcer index of gastric ulcer in pantoprazole sodium group and levopolalate sodium group was significantly lower than that in model control group, and the ulcer inhibition rate was significantly higher than that in model control group (P <0.05). L-pantoprazole sodium group rats gastric ulcer index was significantly lower than the pantoprazole sodium group, and the ulcer inhibition rate was significantly higher than the pantoprazole sodium group, the difference was statistically significant (P <0.05). The incidence of total ulcer in the pantoprazole sodium group and levopival prazosate sodium group was significantly lower than that in the model control group (P <0.05), and the total ulcer in the L-pantoprazole sodium group The rate was 40.0%, which was significantly lower than that of the pantoprazole sodium group (75.0%). The difference was statistically significant (P <0.05). Conclusion L-pantoprazole sodium treatment of pylorus ligation rat model of gastric ulcer with good results.