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目的 比较下腹部手术后0-2% 罗哌卡因(Rop) 或0-2% 布比卡因(Bup) 与吗啡(Mor)配伍病人自控硬膜外镇痛(PCEA) 的效应。方法 选择经腹子宫全切术的病人66 例(ASAⅠ~Ⅱ级),随机分成三组双盲对照观察,R组(n= 22):镇痛药为0-2% Rop +0-01% Mor,采用英国Graseby- 9300 PCA泵,以LCP模式给药;B组(n=22) :镇痛药为0-2 % Bup +0-01 % Mor,PCA方法同R组;C组(n = 22):镇痛药为0-9% 生理盐水+ 0-01%Mor(对照组),其方法同R组。结果 R组、B组、C组24 h PCEA所需的镇痛液量分别为20-3 ±5-1 mL,20-2 ±4-4 mL,26-4±7-2 mL;镇痛效果:R组≈B组> C组( P< 0-01~0-05),表现为:R组、B组分别从PCEA45 min 静息和咳嗽时VAS评分一直明显低于C组;D/D比值:C组> R组≈B组( P< 0-05) ,三组病人术后下肢受阻滞的运动神经恢复至Bromage-2 级所需的时间B 组> R组> C 组( P< 0-05),术后2 h 无运动阻滞的病人R 组为64% ,B组36 % ,C组76% ,术?
Objective To compare the effects of self-controlled epidural analgesia (PCEA) with 0-2% Rop or 0-2% Bup with morphine after lower abdominal surgery. Methods Sixty-six patients (ASA Ⅰ ~ Ⅱ) undergoing total abdominal hysterectomy were randomly divided into three groups. The patients in group R (n = 22) were treated with 0-2% Rop and 0-01% Mor Group B (n = 22): analgesics were 0-2% Bup + 0-01% Mor and PCA was the same as Group R; Group C (n = 22) ): Analgesics 0-9% saline + 0-01% Mor (control group), the same method with the R group. Results The amount of analgesia required for 24 h PCEA in groups R, B and C were 20-3 ± 5-1 mL, 20-2 ± 4-4 mL and 26-4 ± 7-2 mL, respectively. Analgesia Results: The VAS scores of group R and group B were significantly lower than those of group C (P <0.01) D ratio: C group> R group ≈B group (P <0-05), the time required for recovery of the motor nerve in the lower limbs to the Bromage-2 level was lower in the three groups. Group B> R group> C group P <0-05). The patients in group R were 64% in group B, 36% in group B and 76% in group C at 2 hours after operation