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目的：了解南方医科大学附属郑州人民医院2013年大肠埃希菌分布及其对常用抗菌药物的耐药性，为临床选择抗菌药物提供参考。方法对2013年各科室标本中分离的630株大肠埃希菌进行抗菌药物敏感试验，依据2010年 CLSI 标准判读，并进行分析。结果630株大肠埃希菌中以中段尿、脓液及痰液检出最多，分别占50.00％、26.67％、17.94％。大肠埃希菌对一、二、三代头孢菌素，庆大霉素及喹诺酮类药物的耐药率较高，对阿米卡星、头孢西丁、碳青霉烯类抗菌药物、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦的敏感性好，但出现了2株耐碳青霉烯类抗菌药物的大肠埃希菌。结论大肠埃希菌是泌尿道感染的常见致病菌，其对常用的抗菌药物耐药率较高。规范使用抗菌药物对防止和延缓细菌耐药具有重要意义。“,”Objective To analyze the distribution of Escherichia coli and antimicrobial resistance of commonly anti -bacterial agents,provide the basis for clinical selection of antibacterial drugs. Methods Antimicrobial sensitivity tests of 630 strains Escherichia coli was performed for the Escherichia coli strains isolated from various clinical specimens in 2013. The result was determined according to the CSLI,2010 edition and was analyzed retrospectively. Results A total of 630 strains of esche-richia coli isolated,most were isolated from the urine,pus and sputum,accounted for 50. 00% ,26. 67% and 50. 00% respec-tively. Escherichia coli show high resistance to first - ,second - ,third - generation cephalosporins,gentamicin and quinolo-ne. It was more sensitive to carbapenems,cefperazone - sulbactam,piperacillin - tazobactam,cefoxitin and amikacin;but there were two Escherichia coli strains were resistant to carbapenems. Conclusion Escherichia coli is a type of common patho-gen causing urinary trat infection. It show high resistance to common antibiotics. The rational use of antimicrobials is of great significance to prevent and delay the bacterial resistance.